American International Journal of Biology and Life Sciences https://www.acseusa.org/journal/index.php/aijbls <p><strong>Aims and Scope</strong></p> <p>American International Journal of Biology and Life Sciences is an internationally refereed journal, published by the American Center of Science and Education, United States. The journal is published in both print and online versions. The online version is free to access and download. The journal accepts article submissions by e-mail (<a href="mailto:aijbls@acseusa.org">aijbls@acseusa.org</a>).</p> <p>The subject areas include, but are not limited to the following fields:</p> <ul> <li>Hydrobiology</li> <li>Neurobiology</li> <li>Developmental Biology</li> <li>Molecular Biology</li> <li>Biochemistry</li> <li>Biophysics, and Biotechnology</li> <li>Biology</li> <li>Life Science</li> <li>Anatomy, Botany</li> <li>Cytology</li> <li>Genetics</li> <li>Microbiology</li> <li>Physiology</li> <li>Zoology</li> <li>Ecology</li> </ul> <p style="text-align: justify; color: #ff0000;"><em><strong>It is important to mention that all the works are showed without any kind of payment. All of them are published free from payments or taxes.</strong></em></p> <p><strong>Features</strong></p> <ul> <li><strong>First Review: </strong><span style="float: none;">The editor or Managing Editor decides whether the article fits within the journal’s aims and scope. Next, a check for the similarity rate is completed using Turnitin. Any manuscripts out of the journal’s scope or having plagiarism, including self-plagiarism, are rejected without peer-reviewed.</span></li> <li><strong>Peer Review:</strong> We use a double-blind system for peer review; both reviewers' and authors’ identities remain anonymous. The paper will be peer-reviewed by three experts; two reviewers from outside and one editor from the journal are typically involved in reviewing a submission. The review process may take 5-6 weeks.</li> <li><strong>DOIs at the Article Level: </strong>Each paper published in American International Journal of Biology and Life Sciences is assigned a <a href="https://www.doi.org/" target="_blank" rel="noopener">DOI</a> number, <a href="https://www.doi.org/" target="_blank" rel="noopener">Click HERE</a> to know what is DOI (Digital Object Identifier).</li> <li><strong>High Visibility</strong><strong>: </strong>American International Journal of Biology and Life Sciences is indexed by Google Scholar.</li> <li>American Center of Science and Education takes the responsibility to enforce a rigorous peer-review together with strict ethical policies and standards to ensure adding high-quality scientific works to the field of scholarly publication. Unfortunately, cases of plagiarism, data falsification, inappropriate authorship credit, and the like, do arise. American Center of Science and Education takes such publishing ethics issues very seriously and our editors are trained to proceed in such cases with a zero-tolerance policy. To verify the originality of content submitted to our journals, we use <span style="float: none;">Turnitin</span> to check submissions against previous publications. American Center of Science and Education works with <a style="box-sizing: border-box; background-color: transparent; color: #0f5a9c; cursor: pointer;" title="" href="https://publons.com/about/home/" target="_blank" rel="noopener">Publons</a> to provide reviewers with credit for their work.</li> </ul> American Center of Science and Education en-US American International Journal of Biology and Life Sciences 2641-5615 IL-10 AND IL-35 AS INFLAMMATION REGULATORS IN PATIENTS WITH ALLERGIC RHINITIS AND MILD ATOPIC ASTHMA https://www.acseusa.org/journal/index.php/aijbls/article/view/229 <p><em>Background.</em><em> Significantly less is known about the immunoregulative cytokines, especially in allergic airway disease.&nbsp;This study aims to present the involvement of IL-35 and IL-10 in patients with allergic rhinitis (AR) and allergic bronchial asthma (BA).&nbsp;Methodology. The&nbsp;study comprised 71 patients –AR, patients with concomitant AR and mild atopic BA, and healthy controls (HC).&nbsp;We examined the serum levels of IL-35 and IL-10, along with other instrumental examinations, between March and September 2021. Findings.&nbsp;Levels of the regulatory cytokines IL-35 and IL-10 were significantly lower in patients than in HC</em><em> (87.19±11.90 </em><em>vs. 96.12±1.79 pg/ml; and 30.26±17.55 vs. 111.56±65.03 pg/ml, respectively).&nbsp;Furthermore, threefold higher serum IL-10 levels were found in healthy subjects compared to patients (p = 0.006).&nbsp;No difference in the levels of interleukins was found between the studied groups. Conclusions.</em><em> Our results indicate that elevated IL-35 and IL-10 may play an essential role in reducing the activity of underlying allergic inflammation in allergic respiratory diseases</em><em>, although no difference in the levels of the studied cytokines was found between the different groups of patients.&nbsp;Therefore, we can speculate that the immunosuppressive cytokines&nbsp;</em><em>IL-35 and IL-10&nbsp;were involved in maintaining the healthy state of no inflammation.</em></p> Kremena Naydenova Antoaneta Mihova Alexander Kukov Tsvetelina Velikova Copyright (c) 2022 Kremena Naydenova, Antoaneta Mihova, Alexander Kukov, Tsvetelina Velikova https://creativecommons.org/licenses/by/4.0 2022-01-06 2022-01-06 4 1 1 12 10.46545/aijbls.v4i1.229