IL-10 AND IL-35 AS INFLAMMATION REGULATORS IN PATIENTS WITH ALLERGIC RHINITIS AND MILD ATOPIC ASTHMA

Main Article Content

Kremena Naydenova
Antoaneta Mihova
Alexander Kukov
Tsvetelina Velikova

Abstract

Background. Significantly less is known about the immunoregulative cytokines, especially in allergic airway disease. This study aims to present the involvement of IL-35 and IL-10 in patients with allergic rhinitis (AR) and allergic bronchial asthma (BA). Methodology. The study comprised 71 patients –AR, patients with concomitant AR and mild atopic BA, and healthy controls (HC). We examined the serum levels of IL-35 and IL-10, along with other instrumental examinations, between March and September 2021. Findings. Levels of the regulatory cytokines IL-35 and IL-10 were significantly lower in patients than in HC (87.19±11.90 vs. 96.12±1.79 pg/ml; and 30.26±17.55 vs. 111.56±65.03 pg/ml, respectively). Furthermore, threefold higher serum IL-10 levels were found in healthy subjects compared to patients (p = 0.006). No difference in the levels of interleukins was found between the studied groups. Conclusions. Our results indicate that elevated IL-35 and IL-10 may play an essential role in reducing the activity of underlying allergic inflammation in allergic respiratory diseases, although no difference in the levels of the studied cytokines was found between the different groups of patients. Therefore, we can speculate that the immunosuppressive cytokines IL-35 and IL-10 were involved in maintaining the healthy state of no inflammation.

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How to Cite
Naydenova, K. ., Mihova, A. ., Kukov, A. ., & Velikova, T. . (2022). IL-10 AND IL-35 AS INFLAMMATION REGULATORS IN PATIENTS WITH ALLERGIC RHINITIS AND MILD ATOPIC ASTHMA. American International Journal of Biology and Life Sciences, 4(1), 1–12. https://doi.org/10.46545/aijbls.v4i1.229
Section
Original Articles/Review Articles/Case Reports/Short Communications
Author Biographies

Kremena Naydenova, Medical University of Sofia, Bulgaria

Assistant Professor

Clinical Center of Allergology

University Hospital Alexandrovska

Medical University of Sofia, Sofia, Bulgaria

Antoaneta Mihova, Sofia University, Bulgaria

Biologist

Clinical Immunology Department

University Hospital Lozenetz

Sofia University, Sofia, Bulgaria

Alexander Kukov, University Hospital Lozenetz, Bulgaria

Biologist

Clinical Immunology Department

University Hospital Lozenetz, Sofia, Bulgaria

Tsvetelina Velikova, Sofia University, Bulgaria

Assistant Professor

Clinical Immunology Department

University Hospital Lozenetz

Sofia University, Sofia, Bulgaria

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